src inhibitor chronic asthma model Search Results


azd5069  (AstraZeneca ltd)
90
AstraZeneca ltd azd5069
Azd5069, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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azd5069 - by Bioz Stars, 2026-06
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airway epithelial cells  (MatTek)
90
MatTek airway epithelial cells
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Airway Epithelial Cells, supplied by MatTek, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/airway epithelial cells/product/MatTek
Average 90 stars, based on 1 article reviews
airway epithelial cells - by Bioz Stars, 2026-06
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bronchial smooth muscle cells (bsmcs) from asthmatic subjects  (Lonza)
90
Lonza bronchial smooth muscle cells (bsmcs) from asthmatic subjects
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Bronchial Smooth Muscle Cells (Bsmcs) From Asthmatic Subjects, supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bronchial smooth muscle cells (bsmcs) from asthmatic subjects/product/Lonza
Average 90 stars, based on 1 article reviews
bronchial smooth muscle cells (bsmcs) from asthmatic subjects - by Bioz Stars, 2026-06
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biomarkers in asthma  (Genentech inc)
90
Genentech inc biomarkers in asthma
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Biomarkers In Asthma, supplied by Genentech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/biomarkers in asthma/product/Genentech inc
Average 90 stars, based on 1 article reviews
biomarkers in asthma - by Bioz Stars, 2026-06
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asthma  (Glaxo Smith)
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Glaxo Smith asthma
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Asthma, supplied by Glaxo Smith, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
asthma - by Bioz Stars, 2026-06
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symptom monitoring device for asthma  (Respiri Inc)
90
Respiri Inc symptom monitoring device for asthma
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Symptom Monitoring Device For Asthma, supplied by Respiri Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/symptom monitoring device for asthma/product/Respiri Inc
Average 90 stars, based on 1 article reviews
symptom monitoring device for asthma - by Bioz Stars, 2026-06
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dual anti-il-4/il-13 human domain ab dom-0910  (Domantis Ltd)
90
Domantis Ltd dual anti-il-4/il-13 human domain ab dom-0910
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Dual Anti Il 4/Il 13 Human Domain Ab Dom 0910, supplied by Domantis Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/dual anti-il-4/il-13 human domain ab dom-0910/product/Domantis Ltd
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dual anti-il-4/il-13 human domain ab dom-0910 - by Bioz Stars, 2026-06
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smartphone  (Symbian Ltd)
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Symbian Ltd smartphone
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Smartphone, supplied by Symbian Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/smartphone/product/Symbian Ltd
Average 90 stars, based on 1 article reviews
smartphone - by Bioz Stars, 2026-06
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chi-square test for trend  (CH Instruments)
90
CH Instruments chi-square test for trend
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Chi Square Test For Trend, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chi-square test for trend - by Bioz Stars, 2026-06
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asthma  (Teva)
86
Teva asthma
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Asthma, supplied by Teva, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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asthma - by Bioz Stars, 2026-06
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promis asthma scale  (ProMIS Neurosciences)
90
ProMIS Neurosciences promis asthma scale
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Promis Asthma Scale, supplied by ProMIS Neurosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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promis asthma scale - by Bioz Stars, 2026-06
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chi-square test  (CH Instruments)
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CH Instruments chi-square test
Experimental design for in vitro wounding of airway <t>epithelial</t> cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines
Chi Square Test, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/chi-square test/product/CH Instruments
Average 90 stars, based on 1 article reviews
chi-square test - by Bioz Stars, 2026-06
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Image Search Results


Experimental design for in vitro wounding of airway epithelial cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines

Journal: Respiratory Research

Article Title: Pharmacologically-induced mitotic synchrony in airway epithelial cells as a mechanism of action of anti-inflammatory drugs

doi: 10.1186/s12931-015-0293-4

Figure Lengend Snippet: Experimental design for in vitro wounding of airway epithelial cultures: Epithelia were pulsed for two hours every 24 h with 20nM dexamethasone (DEX), 10 μM VBP15 (VBP), or vehicle (VEH) at the times shown. Mechanical scrape-wounding occurred at zero hours with continuous BrdU exposure until cell harvest at +48 h for cytokine and mitotic analyses. Media samples were frozen before measurement of inflammatory cytokines

Article Snippet: Non-asthmatic and asthmatic airway epithelial cells (#AIR-606 and #AIR-606-Asthma; MatTek Corp., Ashland, MA) were grown and differentiated at air-liquid interface using previously described protocols [ , , ].

Techniques: In Vitro

VBP15 Improves Mitotic Asynchrony in Asthmatic Human Airway Epithelia: Compared with wounded non-asthmatic epithelial cultures, wounded asthmatic epithelial cultures at +48 h showed a more even distribution of BrdU + cells among the cell cycle phases (i.e., G 1 /G 0 , S, and G 2 /M) consistent with mitotic asynchrony (Left Panel). Pulse exposures of asthmatic epithelial cultures to VBP15 improved cell cycle synchrony as shown by normalization of the percentage of mitotic cells in each cell cycle phase although to a lesser extent than for dexamethasone (DEX)-exposed epithelial cultures. Statistical comparisons of the percentage of BrdU + cells in G 1 /G 0 among conditions are shown (Right Panel). Experiments were conducted in triplicate in N = 3 donors per group. (* p < 0.05 vs. normal vehicle, # p < 0.05 vs. asthma vehicle)

Journal: Respiratory Research

Article Title: Pharmacologically-induced mitotic synchrony in airway epithelial cells as a mechanism of action of anti-inflammatory drugs

doi: 10.1186/s12931-015-0293-4

Figure Lengend Snippet: VBP15 Improves Mitotic Asynchrony in Asthmatic Human Airway Epithelia: Compared with wounded non-asthmatic epithelial cultures, wounded asthmatic epithelial cultures at +48 h showed a more even distribution of BrdU + cells among the cell cycle phases (i.e., G 1 /G 0 , S, and G 2 /M) consistent with mitotic asynchrony (Left Panel). Pulse exposures of asthmatic epithelial cultures to VBP15 improved cell cycle synchrony as shown by normalization of the percentage of mitotic cells in each cell cycle phase although to a lesser extent than for dexamethasone (DEX)-exposed epithelial cultures. Statistical comparisons of the percentage of BrdU + cells in G 1 /G 0 among conditions are shown (Right Panel). Experiments were conducted in triplicate in N = 3 donors per group. (* p < 0.05 vs. normal vehicle, # p < 0.05 vs. asthma vehicle)

Article Snippet: Non-asthmatic and asthmatic airway epithelial cells (#AIR-606 and #AIR-606-Asthma; MatTek Corp., Ashland, MA) were grown and differentiated at air-liquid interface using previously described protocols [ , , ].

Techniques:

VBP15 effectively reduces post-wounding asthmatic epithelial basolateral inflammatory secretions: Levels of cytokines measured by cytometric bead assay are shown for basolateral secretions from asthmatic and non-asthmatic human airway epithelial cells differentiated at air-liquid interface. Measurements were obtained post-injury at +24, and +48 h. Data are shown as mean ± SEM in pg/mL and significance was obtained by t -test using corresponding time points for DMSO vehicle (VEH)-exposed, DEX-exposed, and VBP15-exposed asthmatic cultures. Experiments were conducted in triplicate using N = 3 donors. (* p < 0.05 vs. vehicle, # p < 0.05 vs. DEX)

Journal: Respiratory Research

Article Title: Pharmacologically-induced mitotic synchrony in airway epithelial cells as a mechanism of action of anti-inflammatory drugs

doi: 10.1186/s12931-015-0293-4

Figure Lengend Snippet: VBP15 effectively reduces post-wounding asthmatic epithelial basolateral inflammatory secretions: Levels of cytokines measured by cytometric bead assay are shown for basolateral secretions from asthmatic and non-asthmatic human airway epithelial cells differentiated at air-liquid interface. Measurements were obtained post-injury at +24, and +48 h. Data are shown as mean ± SEM in pg/mL and significance was obtained by t -test using corresponding time points for DMSO vehicle (VEH)-exposed, DEX-exposed, and VBP15-exposed asthmatic cultures. Experiments were conducted in triplicate using N = 3 donors. (* p < 0.05 vs. vehicle, # p < 0.05 vs. DEX)

Article Snippet: Non-asthmatic and asthmatic airway epithelial cells (#AIR-606 and #AIR-606-Asthma; MatTek Corp., Ashland, MA) were grown and differentiated at air-liquid interface using previously described protocols [ , , ].

Techniques: